Bryan Johnson Blueprint
The full blood panel from Bryan Johnson's Blueprint longevity protocol — every marker he tracks, organized into his Essential / Advanced tiers, with the targets he aims for where he states one.
These are ONE person's stated optimization goals — not a clinical reference range, not medical advice, not our recommendation. Every number is reported as publicly documented and attributed to the source.
Objectifs tels que documentés publiquement : longevity.haus. Les objectifs déclarés d'un auteur, ni des valeurs de référence cliniques ni un avis médical.Chaque objectif ci-dessous figure à côté des valeurs qu'un laboratoire nommé publie comme normales, quand nous en avons. Ce sont deux choses différentes : un objectif est le but déclaré de cet auteur, la norme publiée est ce qui fait signaler une valeur par un laboratoire. Les deux sont des chiffres réels, présentés tels que chaque source les donne ; rien ici n'est notre recommandation.
Niveau 1 · Essentiel
Les marqueurs qui changent les décisions : un point de départ raisonnable. Apolipoprotéine B objectif <80 mg/dL norme publiée 60–133 mg/dL * Counts the atherogenic (LDL/VLDL) particles that lodge in artery walls and drive plaque — a more direct cardiovascular-risk measure than LDL cholesterol alone. Cited: Ference et al., JAMA 2019.
C Réactive protéine objectif <0,5 mg/L A sensitive marker of systemic inflammation; lower levels are linked to fewer cardiovascular events. Cited: Ridker et al., NEJM 2008 (JUPITER).
Hémoglobine A1c/hémoglobine totale objectif <5 % norme publiée 4–5,6 % Average blood sugar over roughly three months; staying low within the non-diabetic range tracks with lower metabolic and cardiovascular risk. Cited: Selvin et al., NEJM 2010.
Cholestérol LDL objectif <100 mg/dL The cholesterol carried by atherogenic particles; a large body of genetic and trial evidence ties lower lifelong LDL to less arterial plaque. Cited: Ference et al., Eur Heart J 2017.
Alanine aminotransférase objectif <25 U/L norme publiée 10–40 U/L A liver enzyme; lower within the normal range suggests less liver stress or fat.
Cholestérol objectif <200 mg/dL Total cholesterol across all particles — a coarse screen best read alongside ApoB and LDL, not on its own.
Créatinine norme publiée 0,5–1,3 mg/dL * A kidney-function marker; used with eGFR and cystatin C to estimate filtration.
Cystatine C norme publiée 0,61–0,95 mg/L * A kidney-function marker less affected by muscle mass than creatinine.
Ferritine norme publiée see test The body's iron store; low signals depletion, high can signal inflammation or iron overload.
Folates norme publiée 1,8–9 ng/mL Folate — works with B12 to lower homocysteine and support cell division.
Glucose norme publiée 70–99 mg/dL Fasting blood sugar — a core metabolic marker, best read together with fasting insulin and HbA1c.
Cholestérol HDL objectif >50 mg/dL The 'good' cholesterol fraction; higher is generally associated with lower cardiovascular risk, though it is not itself a treatment target.
Homocystéine objectif <7 umol/L norme publiée see test An amino acid associated with cardiovascular risk; typically inexpensive to lower with B6, B12 and folate. Cited: Wald et al., BMJ 2002.
Insuline norme publiée see test Fasting insulin reveals insulin resistance earlier than glucose does; lower is generally more favorable metabolically.
Thyréostimuline norme publiée see test Thyroid-stimulating hormone — the first-line screen of thyroid function.
Triglycérides objectif <100 mg/dL A blood fat that rises with refined carbohydrate intake and insulin resistance; lower is metabolically favorable.
Cobalamines norme publiée see test Vitamin B12 — needed for nerves and blood, and to help keep homocysteine low.
25-hydroxycholécalciférol+25-hydroxyergocalciférol objectif 60–80 ng/mL norme publiée 30–100 ng/mL Fat-soluble vitamin for bone, immune and muscle function; his target sits above the standard sufficiency cutoff and above some guideline recommendations.
Filtration glomérulaire corrigée/1,73m2 calculée Estimated glomerular filtration rate — the standard measure of overall kidney function.
Niveau 2 · Avancé
Marqueurs avancés, utiles quand vous optimisez activement. Apolipoprotéine AI norme publiée 104–225 mg/dL * The main protein of HDL; the ApoB:ApoA1 ratio refines cardiovascular risk. Cited: Yusuf et al., Lancet 2004 (INTERHEART).
Déhydroépiandrostérone sulfate norme publiée see test An adrenal hormone precursor that declines steadily with age.
Estradiol norme publiée see test The main estrogen — important in both sexes for bone and cardiovascular health.
Triiodothyronine libre norme publiée 2–4,4 pg/mL * Free T3 — the active thyroid hormone at the tissue level.
Thyroxine libre norme publiée 0,8–2,4 ng/dL * Free T4 — the main circulating thyroid hormone, converted to active T3.
Gamma glutamyltransférase norme publiée 5–61 U/L * A liver enzyme sensitive to alcohol and fatty liver; read with ALT and AST.
Insulin-like growth factor 1 norme publiée 15–246 ng/mL * IGF-1 — growth-hormone signaling; a double-edged longevity marker (growth vs. aging pathways).
Lipoprotéine petit a Lipoprotein(a) — a largely genetic, independent cardiovascular risk factor; usually measured once in a lifetime.
Magnésium norme publiée 1,6–2,6 mg/dL * A mineral for hundreds of enzymes; RBC magnesium reflects stores better than serum.
Sex hormone binding globulin norme publiée 13,3–125 nmol/L * Binds sex hormones and sets how much testosterone is actually free.
Testostérone objectif 700–900 ng/dL norme publiée see test The primary male sex hormone; his target is the upper end of the normal adult range.
Testostérone libre norme publiée see test The bioavailable fraction of testosterone not bound to SHBG or albumin.
Thyroperoxidase anticorps norme publiée 0–9 IU/mL Thyroid peroxidase antibodies — flag autoimmune thyroid disease (Hashimoto's).
Triiodothyronine réverse norme publiée 9–27 ng/dL Reverse T3 — an inactive thyroid metabolite that can rise under stress or illness.
Urate norme publiée 3–8,4 mg/dL * Uric acid — high levels tie to gout and to metabolic and cardiovascular risk.
* marks a range that varies by sex or age — see the test for the full breakdown.
Le protocole derrière les objectifs
Blueprint pairs these targets with a strict ~1,950-calorie vegan diet, 100+ supplements, and interventions like HBOT — and the stated lesson is to act on TRENDS over repeated tests, not single values. Example: elevated homocysteine is usually corrected with B6, B12 and folate. Context only, not advice.
Source: longevity.haus