The full blood panel from Bryan Johnson's Blueprint longevity protocol — every marker he tracks, organized into his Essential / Advanced tiers, with the targets he aims for where he states one. These are ONE person's stated optimization goals — not a clinical reference range, not medical advice, not our recommendation. Every number is reported as publicly documented and attributed to the source.
Targets as publicly documented — longevity.haus. An author's stated goals, not a clinical reference range or medical advice.
Each target below sits beside the range a named lab publishes as normal, where we hold one. The two are different things: a target is this author's stated goal, the published normal is what a lab flags against. Both are real numbers, shown as each source states them — nothing here is our recommendation.
Tier 1 · Essential
Counts the atherogenic (LDL/VLDL) particles that lodge in artery walls and drive plaque — a more direct cardiovascular-risk measure than LDL cholesterol alone. Cited: Ference et al., JAMA 2019.
A sensitive marker of systemic inflammation; lower levels are linked to fewer cardiovascular events. Cited: Ridker et al., NEJM 2008 (JUPITER).
Average blood sugar over roughly three months; staying low within the non-diabetic range tracks with lower metabolic and cardiovascular risk. Cited: Selvin et al., NEJM 2010.
The cholesterol carried by atherogenic particles; a large body of genetic and trial evidence ties lower lifelong LDL to less arterial plaque. Cited: Ference et al., Eur Heart J 2017.
A liver enzyme; lower within the normal range suggests less liver stress or fat.
Total cholesterol across all particles — a coarse screen best read alongside ApoB and LDL, not on its own.
A kidney-function marker; used with eGFR and cystatin C to estimate filtration.
A kidney-function marker less affected by muscle mass than creatinine.
The body's iron store; low signals depletion, high can signal inflammation or iron overload.
Folate — works with B12 to lower homocysteine and support cell division.
Fasting blood sugar — a core metabolic marker, best read together with fasting insulin and HbA1c.
The 'good' cholesterol fraction; higher is generally associated with lower cardiovascular risk, though it is not itself a treatment target.
An amino acid associated with cardiovascular risk; typically inexpensive to lower with B6, B12 and folate. Cited: Wald et al., BMJ 2002.
Fasting insulin reveals insulin resistance earlier than glucose does; lower is generally more favorable metabolically.
Serum iron — read alongside ferritin and transferrin saturation.
Thyroid-stimulating hormone — the first-line screen of thyroid function.
A blood fat that rises with refined carbohydrate intake and insulin resistance; lower is metabolically favorable.
Vitamin B12 — needed for nerves and blood, and to help keep homocysteine low.
Fat-soluble vitamin for bone, immune and muscle function; his target sits above the standard sufficiency cutoff and above some guideline recommendations.
Estimated glomerular filtration rate — the standard measure of overall kidney function.
Tier 2 · Advanced
The main protein of HDL; the ApoB:ApoA1 ratio refines cardiovascular risk. Cited: Yusuf et al., Lancet 2004 (INTERHEART).
A trace mineral, balanced against zinc.
The primary stress hormone; follows a daily (diurnal) rhythm.
An adrenal hormone precursor that declines steadily with age.
The main estrogen — important in both sexes for bone and cardiovascular health.
A clotting protein that also rises with inflammation.
Free T3 — the active thyroid hormone at the tissue level.
Free T4 — the main circulating thyroid hormone, converted to active T3.
A liver enzyme sensitive to alcohol and fatty liver; read with ALT and AST.
IGF-1 — growth-hormone signaling; a double-edged longevity marker (growth vs. aging pathways).
Lipoprotein(a) — a largely genetic, independent cardiovascular risk factor; usually measured once in a lifetime.
A mineral for hundreds of enzymes; RBC magnesium reflects stores better than serum.
PSA — the standard prostate screen in men.
A pituitary hormone; high levels can disrupt sex-hormone balance.
Vitamin B6 — works with B12 and folate to lower homocysteine.
Binds sex hormones and sets how much testosterone is actually free.
A trace mineral for thyroid and antioxidant enzymes.
The primary male sex hormone; his target is the upper end of the normal adult range.
The bioavailable fraction of testosterone not bound to SHBG or albumin.
Thyroid peroxidase antibodies — flag autoimmune thyroid disease (Hashimoto's).
Reverse T3 — an inactive thyroid metabolite that can rise under stress or illness.
Uric acid — high levels tie to gout and to metabolic and cardiovascular risk.
A trace mineral for immunity, wound healing and hormones.
The protocol behind the targets
Blueprint pairs these targets with a strict ~1,950-calorie vegan diet, 100+ supplements, and interventions like HBOT — and the stated lesson is to act on TRENDS over repeated tests, not single values. Example: elevated homocysteine is usually corrected with B6, B12 and folate. Context only, not advice.
Source: longevity.haus